About 1 result found for searched term "AZ12253801 " (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30698 | AZ12253801 | IGF-1R |
| AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity. | ||
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